尹敏个人简历-欢迎访问云南大学医学院

美国威斯康辛大学-云南大学微生物学博士，University of Wisconsin-Madison, School of pharmacy, USA和The Scripps Research Institute, Department of Molecular Medicine and Chemistry, USA访问学者。云南省万人（现云南省兴滇英才），云南省科技特派员，云南省优博，云南大学中青年骨干教师。现任医学院新药创制课题组PI、病原生物学教研室主任。

从事病原生物学、微生物组学及抗感染、抗肿瘤新药创制方向的科研工作。以云南药用植物为研究对象，发现了大量产生活性分子潜力的微生物资源，并从中获得了多类活性药物分子，阐释了重要分子的生物合成机制，构建了大量遗传改造工程菌株，为药物分子的药理学研究及实际应用奠定了坚实的基础；结合微生物组学探讨了病原生物的致病机制；结合基因改造技术开展了病原微生物疫苗研发及应用工作。

主持国家级、省部级、厅级等项目 12 项，项目总经费552万元。在ACS Catalysis、Organic letters、Nature Communications等期刊发表论文60多篇，其中一篇论文入选ESI高被引论文。担任Nature Communications等多个SCI期刊审稿人。出版专著4部。获得授权专利8项。

部分项目：

1. 国家自然科学基金地区基金项目，2022/01-2025/12，在研，35万元。

2. 国家自然科学基金地区基金项目，2019/01-2022/12，结题，41.8万元。

3. 国家自然科学基金地区基金项目，2016/01-2019/12，结题，48万元。

4. 云南省自然科学基金重点项目，2022/06-2025/05，在研，50万元。

5. 云南实验室专项，2025/1-2026/12，在研，300万元。

部分论文：

中科院一区期刊论文

1. J. Tang, X. Guo, J. Yang, Y.-J. Wang, J. Luo, M. Yin*, Y. Yan*, S.-X. Huang*, Uncovering the Parallel Biosynthetic Pathways of the Cyclohexanone and Phenol Rings in Cycloheximide and Actiphenol by Tailoring Redox Enzymes. ACS Catalysis 14, 13148-13155 (2024). （通讯，影响因子=11.3）

2. M. Yin, Y. Yan, J. R. Lohman, S. X. Huang, M. Ma, G. R. Zhao, L. H. Xu, W. Xiang, B. Shen, Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Organic letters 16, 3072-3075 (2014); published online EpubJun 6 (10.1021/ol501179w).（一作，影响因子=6.072，Nature Index）

3. M. Yin, T. Lu, L. X. Zhao, Y. Chen, S. X. Huang, J. R. Lohman, L. H. Xu, C. L. Jiang, B. Shen, The missing C-17 O-methyltransferase in geldanamycin biosynthesis. Organic letters 13, 3726-3729 (2011); published online EpubJul 15 (10.1021/ol201383w).（一作，影响因子=6.072，Nature Index）

4. Sun X, Qian M, Li H, Wang L, Zhao Y, Yin M*, Dai L*, Bao H*. FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment. Cell Death Dis. 2023 Nov 11;14(11):736. doi: 10.1038/s41419-023-06260-7. PMID: 37952053; PMCID: PMC10640650.（通讯，影响因子=9.0）

5. Shu-Kun Tang, Xiao-Yang Zhi, Yao Zhang, Kira-S. Makarova, Bing-Bing Liu, Guo-Song Zheng, Zhen-Peng Zhang, Hua-Jun Zheng,Yuri-I. Wolf, Yu-Rong Zhao, Song-Hao Jiang, Xi-Min Chen, En-Yuan Li,Tao Zhang, Pei-Ru Chen, Yu-Zhou Feng, Ming-Xian Xiang, Zhi-Qian Lin, Jia-Hui Shi, Cheng Chang, Xue Zhang, Rui Li, Kai Lou, Yun Wang,Lei Chang, Min Yin, Ling-Ling Yang, Hui-Ying Gao, Zhong-Kai Zhang,Tian-Shen Tao, Tong-Wei Guan, Fu-chu He, Yin-Hua Lu, Heng-Lin Cui,Eugene-V. Koonin, Guo-Ping Zhao，Ping Xu, Cellular differentiation into hyphae and spores in halophilic archaea. Nature communications. (Nature Index, 中科院一区top，影响因子= 16.6)

6. Shouqi Zhang , Wang Kaibiao , Liu Yuanning , Tao Wang , Kong Yao , Pengcheng Zhang , Bo Zhang , Min Yin , Guohui Pan , Zhengren Xu, An Isopentenol Utilization Pathway-Based “Deuterium-Scanning” Method for Mechanistic Investigations of Terpene Cyclases, ACS Catalysis 14, 17598-17608 (2024). （中科院一区top，影响因子=11.3）

中科院二区期刊论文：

7. Y. Wu, L. Ran, Y. Yang, X. Gao, M. Peng, S. Liu, L. Sun, J. Wan, Y. Wang, K. Yang, M. Yin*, W. Chunyu*, Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota. Life Sciences 314, (2023)https://doi.org/10.1016/j.lfs.2022.121312).（通讯，影响因子= 6.780，ESI顶尖论文）

8. G. Li, Z. Zhang, M. Wu, X. Chen, M. Yin*, Y. Jiang*, X. Huang, C. Jiang, L. Han*, The discovery of germacradienol synthase: Construction of genetically-engineered strain, glycosylated modification, bioactive evaluation of germacradienol. Bioorganic chemistry 124, 105819 (2022); published online EpubApr 20 (10.1016/j.bioorg.2022.105819).（通讯，影响因子= 5.307）

9. T. Liu, Z. Ren, W. X. Chunyu, G. D. Li, X. Chen, Z. T. Zhang, H. B. Sun, M. Wang, T. P. Xie, M. Wang, J. Y. Chen, H. Zhou*, Z. T. Ding*, M. Yin*, Exploration of Diverse Secondary Metabolites From Streptomyces sp. YINM00001, Using Genome Mining and One Strain Many Compounds Approach. Frontiers in microbiology 13, 831174 (2022)10.3389/fmicb.2022.831174).（通讯，影响因子= 6.064）

10. R. Li, M. Wang, Z. Ren, Y. Ji, M. Yin*, H. Zhou*, S. K. Tang*, Amycolatopsis aidingensis sp. nov., a Halotolerant Actinobacterium, Produces New Secondary Metabolites. Frontiers in microbiology 12, 743116 (2021)10.3389/fmicb.2021.743116).（通讯，影响因子= 6.064）

11. L. Sun, M. Zhu, L. Zhang, M. Peng, C. Li, L. Wang, W. Wang, Z. Ma, S. Li, W. Zeng, M. Yin*, W. Wang*, W. Chunyu*, Differences in microbiome of healthy Sprague Dawley rats with Paragonimus proliferus infection and potential pathogenic role of microbes in paragonimiasis. Acta tropica 233, 106578 (2022); published online EpubSep (10.1016/j.actatropica.2022.106578).（通讯，影响因子= 3.222）

12. M. Yin*, G. Li, Y. Jiang, L. Han, X. Huang, T. Lu, C. Jiang, The complete genome sequence of Streptomyces albolongus YIM 101047, the producer of novel bafilomycins and odoriferous sesquiterpenoids. Journal of biotechnology 262, 89-93 (2017); published online EpubNov 20 (10.1016/j.jbiotec.2017.09.018).（通讯，影响因子= 3.595）

13. M. Yin, M. Jiang, Z. Ren, Y. Dong, T. Lu*, The complete genome sequence of Streptomyces autolyticus CGMCC 0516, the producer of geldanamycin, autolytimycin, reblastatin and elaiophylin. Journal of biotechnology 252, 27-31 (2017); published online EpubJun 20 (10.1016/j.jbiotec.2017.04.037).（一作，影响因子= 3.595）

14. M. Jiang, M. Yin, S. Wu, X. Han, K. Ji, M. Wen, T. Lu, GdmRIII, a TetR Family Transcriptional Regulator, Controls Geldanamycin and Elaiophylin Biosynthesis in Streptomyces autolyticus CGMCC0516. Scientific reports 7, 4803 (2017); published online EpubJul 6 (10.1038/s41598-017-05073-x). （一作，影响因子= 4.996）

15. M. Peng, L. Wang, H. Su, L. Zhang, Y. Yang, L. Sun, Y. Wu, L. Ran, S. Liu, M. Yin*, S. Li, W. Chunyu*, Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats. Journal of food biochemistry 46, e14321 (2022); published online EpubOct (10.1111/jfbc.14321). （通讯，影响因子= 3.654）

16. Y. Chen, M. Yin, G. P. Horsman, B. Shen, Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. Journal of natural products 74, 420-424 (2011); published online EpubMar 25 (10.1021/np100825y). （中科院二区，影响因子= 4.803）

17. H. Li, H. Chen, H. Wang, Y. Dong, M. Yin, L. Zhang, J. Wei, MicroRNA-374a Promotes Hepatocellular Carcinoma Cell Proliferation by Targeting Mitogen-Inducible Gene 6 (MIG-6). Oncology research 26, 557-563 (2018); published online EpubMay 7 . （中科院二区，影响因子= 4.938）

18. P. Xie, M. Ma, M. E. Rateb, K. A. Shaaban, Z. Yu, S. X. Huang, L. X. Zhao, X. Zhu, Y. Yan, R. M. Peterson, J. R. Lohman, D. Yang, M. Yin, J. D. Rudolf, Y. Jiang, Y. Duan, B. Shen, Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Journal of natural products 77, 377-387 (2014); published online EpubFeb 28 (10.1021/np401063s). （中科院二区，影响因子= 4.803）