李宏亮，博士，副研究员，硕士研究生导师，云南大学中青年骨干教师。

毕业院校：中山大学

研究方向：神经药理（抗阿尔兹海默药理）和肿瘤药理学。

联系方式：lihongliang@ynu.edu.cn

办公地址：昆明市五华区翠湖北路2号云南大学医学院

代表论文：

1. TQ Dong, YC Yuan, XD Xiang, ...... HL Li (corresponding author). High cytoplasmic YAP1 expression predicts a poor prognosis in patients with colorectal cancer. PeerJ. 2020;8: e10397.

2.Yao Bai, Lingling Chen, Yao Chen, ...... Hongliang Li(corresponding author). A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance. RSC Adv., 2019, 9, 37127–37135.

3.Linlin Fan, Lingling Chen, Zhi Liang......Hongliang Li(corresponding author). A Polysaccharide Extract from Maitake Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice.International Journal of Medicinal Mushrooms, 21(11):1065 –1074 (2019).

4.HL Li,Guo X, Li Q, et al., Long non-coding RNA 1308 promotes cell invasion by regulating the miR-124/ADAM 15 axis in non-small-cell lung cancer cells. Cancer Manag Res, 2018. 10: p. 6599-6609.

5.Hongliang Li, Shuxian Chen ,  Jia Liu, et al, Long non-coding RNA PVT1-5 promotes cell proliferation by regulating miR-126/SLC7A5 axis in lung cancer. Biochem Biophys Res Commun, 2018, 495(3): 2350-2355.

6.Hongliang Li,Xueding Wang,Yangfang Zhou, et al. Association of LEPR and ANKK1gene polymorphisms with weight gain in epilepsy patients receiving valproic acid. International Journal of Neuropsychopharmacology 2015; DOI: 10.1093/ijnp/pyv021.

7.Xu GL, Li HL(co-fist author)，He JC, et al. Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid. Journal of Ethnopharmacology, 149 (2013) 49–54.

8.Li HL, He JC, Bai M, et al. Determination of the plasma pharmacokinetic and tissue distributions of swertiamarin in rats by liquid chromatography with tandem mass spectrometry. Arzneimittelforschung, 62 (2012)138-144.

9.Li HL, Peng XJ, He JC, et al. Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics. Journal of Chromatography B, 879 (2011) 1653–1658.

项目：

1.国家自然科学基金，81860638，基于Dectin-1/TLR4/GSK3β信号轴协同调控神经免疫和突触可塑性改善学习记忆的药理新机制，主持, 2019.01-2022.12，35万元。

2.云南省科技厅面上项目，202101AT070153，Dectin-1受体介导AD小鼠脑内小胶质细胞免疫动态演进过程和药理干预研究，主持，2021.04-2024.03，10万元。

3.云南省科技厅面上项目，2017FB138，灰树花β-葡聚糖调控AMPA及固有免疫受体Dectin-1对AD模型小鼠记忆和认知的作用研究，主持，2017.06-2020.05，10万元。

4.云南省教育厅基金，2016ZZX014，野生菌灰树花中活性成分调控AMPA/Dectin 1受体对AD模型小鼠的作用研究，主持，2016.09-2018.12，4万元。

5.入选云南大学中青年骨干教师培养计划（2018年），人才培养计划。